DON PEYOTE tells the story Warren Allman, an unemployed stoner who finally finds a purpose in life after an unpleasant encounter with a homeless man preaching the end is near. Fueled by vivid apocalyptic dreams, Warren becomes obsessed with 2012 doomsday theories and decides to make a documentary on the subject while his fiance is busy planning their wedding.

Bob and Walt Tenor are twin brothers, who not only share a passion for life, but also a liver. Thanks to their teamwork, being conjoined twins is not a handicap to them. But, when Walt's dreams of stardom of acting on the screen and Bob's shyness clashes, they both begin to fall out. This doesn't help when Bob's Internet girl arrives in town, unaware of their handicap, and when Walt gains his own TV show with Cher.